Antigen-Induced Expression of CD203c on Basophils Predicts IgE-mediated Wheat Allergy

Antigen-induced expression of CD203c on basophils predicts IgE-mediated wheat allergy.

BACKGROUND For in vitro diagnosis of wheat allergy, specific IgE to wheat is known to be a poor predictive marker. Oral food challenge, the gold standard for the diagnosis, is accompanied by a risk of severe induced reactions. Reliable in vitro tests are needed to be developed for safe indication for oral challenge. OBJECTIVE We examined the utility of a basophil activation marker, CD203c, fo...

IgE-MEDIATED ALLERGY TO DIETARY GLIADIN: STUDIES ON WHEAT-DEPENDENT, EXERCISE-INDUCED ANAPHYLAXIS AND CHILDHOOD WHEAT ALLERGY

Age of resolution from IgE-mediated wheat allergy.

BACKGROUND The natural history of wheat allergy varies among different countries. OBJECTIVE To study the age of resolution from IgE-mediated wheat allergy and to define the predictors of wheat tolerance. METHODS Patients with a history of immediate reactions after wheat ingestion were enrolled. Skin prick test (SPT) and measurement of serum specific IgE (sIgE) to wheat and ω-5 gliadin were ...

Cerivastatin and atorvastatin inhibit IL-3-dependent differentiation and IgE-mediated histamine release in human basophils and downmodulate expression of the basophil-activation antigen CD203c/E-NPP3.

Recent data suggest that the statins, apart from their lipid-lowering activity, exhibit profound anti-inflammatory effects. Basophils are major proinflammatory effector cells in diverse pathologic reactions. We have examined the in vitro effects of five different statins on primary human basophils, their progenitors, and the basophil cell line KU-812. Preincubation of blood basophils with ceriv...

IgE-mediated food allergy.

The behaviour of some immunologic parameters was studied in order to explain the presence or the lack of symptomatology in subjects with IgE specific to foods. In particular, we compared the levels of serum and salivary IgA and IgE antibody specific to apple in 33 patients allergic to birch and with anti-apple IgE, of whom 24 had oral allergy syndrome after eating apple and nine were apple tole...